factory Chinap-Hydroxyacetophenone 99-93-4p-Acetylphenol 99-93-4 CAS NO.99-93-4

factory Chinap-Hydroxyacetophenone 99-93-4p-Acetylphenol 99-93-4

Paraben ethyl ketone, because its molecules contain hydroxyl and ketone-based benzene rings, is often used as an organic synthesis of intermediates and other compounds in reaction to the synthesis of many important substances. Generally used to synthesize pharmaceutical intermediates (α-bromine-parabens, lilies, anti-heat analgesics and other drugs), others (spices, feed, etc.; pesticides, dyes, liquid crystal materials, etc.).

Production method
It is obtained by the acetylation and transposure of phenol. Mix phenol with acetylchloride and heat it slowly until hydrogen chloride stops escaping, resulting in crude acetylene. Add nitrobenzene, add aluminum trichloride under cooling, and stir 2-3h at room temperature after addition. Then pour in cold water and add 1:3 hydrochloric acid until clear. Extracted with ether, then recovered ether with extract, and then water vapor distillation, nitrobenzene and by-products of phthalates at any time water vapor steam out, parabens left in the residue. Extract residual liquid with ether, recover ether after cooling crystallization is crude, recrystallization with water is the finished product. The above-mentioned acetylation operation can replace acetylchlorine with acetyl chloride, and heat phenol and acetylene back to flow back 3h, i.e. to produce acetylene, the yield is about 83%. The translocation under the action of aquawaterless aluminum trichloride can also be free of solvents. In addition, sodium nitrite heavy nitride, hydrolysis can also be made of paraben ethyl ketone.

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